This is my actual stack, been using Enferno for years, ReadyKit is just the SaaS layer on top. No straying, more like cleaning up what I already run in production.

Stack choices: Flask for its elegant simplicity without hidden conventions, Vue with Vuetify over CDN to skip build-tool pain (massive productivity and time win btw), PostgreSQL because boring is reliable, Redis (optional) for sessions and caching, and Celery when background jobs are needed (optional too)