In Itanium's heyday, the compilers and libraries were pretty good at handling HPC workloads, which is really the closest anyone was running then to modern NN training/inference. The problem with Itanium and its compilers was that people obviously wanted to run workloads that looked nothing like HPC (databases, web servers, etc) and the architecture and compilers weren't very good at that. There have always been very successful VLIW-style architectures in more specialized domains (graphics, HPC, DSP, now NPU) it just hasn't worked out well for general-purpose processors.