>Vaccinated individuals were older than unvaccinated individuals (mean [SD] age, 38.0 [11.8] years vs 37.1 [11.4] years), more frequently women (11 688 603 [51.3%] vs 2 876 039 [48.5%]) and had more cardiometabolic comorbidities (2 126 250 [9.3%] vs 464 596 [7.8%]).

This is interesting because of "supposed" cardiovascular effects of the vaccine that many folks were worried about. Even more confounding is the gender differences. You'd think skewing women would skew away from cardiovascular issues.

An alternate interpretation is that the at risk cardio unvaccinated died of COVID for some reason.

The increase in myocarditis from the vaccine is well-documented. (And very small.)

COVID causes myocarditis too (even for young people unlikely to die from COVID itself), at much higher rates. So you only need a 20% chance of contracting COVID for the vaccine to be net positive in the least obviously positive age group.

> First, individuals who choose vaccination may differ from those who do not, potentially introducing confounding bias.

It's very hard to interpret this data given the massive confounder of "antivaxxers are suspicious of healthcare and take more risks".

I'm not sure what you're trying to say.

Your cite reads to me like a statement on the available data, which is interesting in its own ways but can be corrected for when it's irrelevant to the hypothesis.