> no increased risk of all-cause mortality

> study including 22.7 million vaccinated individuals and 5.9 million unvaccinated individuals

These are the important bits for the non medical folks

lentil_soup 4 hours ago | parent | next [-]

And this bit:

"vaccinated individuals had a 74% lower risk of death from severe COVID-19 and no increased risk of all-cause mortality"

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gwerbret 4 hours ago | parent | prev | next [-]

> These are the important bits for the non medical folks

Also significantly: "vaccinated individuals consistently had a lower risk of death, regardless of the cause."

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attila-lendvai 3 hours ago | parent [-]

that in itself could be healthy user bias (if a healthier subset was taking up the vaccine).

did they control for that?

	▲	biophysboy 3 hours ago \| parent [-]
		Its a cohort study, so you can only control for confounders. The 2nd paragraph of the discussion addresses the healthy-vaccinee effect you're referring to.

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blindriver 4 hours ago | parent | prev [-]

They define unvaccinated as anyone who wasn't vaccinated by Nov 2021. What if they got vaccinated afterwards?

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biophysboy 2 hours ago | parent | next [-]

This is specified as an exclusion criteria in the Supplementary.

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blindriver 2 hours ago | parent [-]

No they didn't. They excluded those that got the vaccine pre-May 2021 or those that got another vaccine besides Pfizer or Moderna.

	▲	biophysboy 2 hours ago \| parent [-]
		The target trial emulation specifies "individuals deceased or vaccinated during the 6 month grace period between the index date and the effective start of follow-up" as an exclusion criteria

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jmye 3 hours ago | parent | prev [-]

What specific impact do you think that would have on this study? Do you think vaccines prior to Nov-2021 were safe and they were unsafe after? Do you think short term results, captured after Nov-2021 are more relevant than inclusive results prior?