I remember I saw a meta review that claimed in the abstract that "analysis showed a rapid regain of weight after cessation of therapy", but then looking into it deeper actually quite a bit of weight loss was retained even many months after stopping.

In my personal experience I've now known about 12 people who've taken it and stopped, and none have "rapidly" regained, in fact many have retained most of their loss for significant periods of time. Most people gain weight over a long period of time (from lets say early teen to their current age).

What happens when they stop is a very slow return to baseline gain. So if it took them 10 years to become obese, then it takes 6-12 months to lose it all with Tirzepatide, you'd expect it would take them 10 years again to regain it.

People act like this is some sort of addiction, but I don't think so - and I'd bet that a "refresher" that was only a small % of the year would keep most people completely at baseline, and they could even slowly taper that down.