I know we can tell that a chemical does a particular thing in the body, but can we tell that it does not do anything other than that thing? The body is ridiculously complex, and as far as I know we don’t know how every part (or combination of parts) works.

Edit: I mean in the theoretical “this targets the x receptor” kind of way, not in “we tested this and found no causal link” way.

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KittenInABox 7 hours ago | parent [-]

That's why I'm genuinely asking why this would be disappointing, like what was the evidence that this does affect Alzheimer's. You would expect by X does not affect Y by default, so clearly there had to be a theory why you'd spend 2 years on a study to rule it out.

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FeteCommuniste 6 hours ago | parent | next [-]

Significant, sustained weight loss can prevent or reduce the effects of conditions known to increase the likelihood or hasten the onset of Alzheimer's, like diabetes and high blood pressure.

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twosdai 7 hours ago | parent | prev | next [-]

This is anecdotal, I don't have proof but it's something I think is somewhat related. Is that obesity and nuerodegenerative diseases are somewhat related. So that's a guess as to why some people might have though a weight loss drug would potentially be related in some way with alzheimers.

This could just be false though, I can't recall where I heard this information. So do some searching before quoting me.

	▲	FeteCommuniste 6 hours ago \| parent [-]
		Obesity often goes hand in hand with poorly regulated blood sugar and high blood pressure, both known risk factors for Alzheimer's.

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habinero 7 hours ago | parent | prev [-]

Ozempic is a diabetes drug, and there's a hypothesis that Alzheimer's is really a form of diabetes.

	▲	bluesounddirect 2 hours ago \| parent [-]
		Personally, living with two T1D ( type 1 insulin dependent diabetic, the autoimmune disease not to be confused with the i am old, fat and over eat disorder) when your blood sugar is too high or low , you act weird , you are in a fog . Long term effects of the swings and sustained levels cause brain damage, not necessarily traumatic brain injuries but damage nonetheless. So i can see the correlation for T1D and undiagnosed T2D cases Alzheimers. Now having a parent with both T2D and Alzheimers when they were taking rebelsis there was a change in their overall mood and activity , but i saw the change was "hey your sugar is under control, and no i am not your buddy from the army" . To be clear the difference is the fog of being unclear about what's going on like you're drunk , vs the grand delusions of seeing a different person that's not there . This should have been obvious for the researchers.