You can go very far with just node alone (accepts typescript without tsc, has testing framework,...). Include pg library that has no dependencies. Build a thin layer above node and you can have pretty stable setup. I got burnt so many times that I think it is simply impossible to build something that won't break within 3 months if you start including batteries.

When it comes to frontend, well I don't have answers yet.

You can write simple front-end without reactive components. Most pages are not full blown apps and they were fine for a very long time with jQuery, whose features have been largely absorbed into plain js/dom/CSS.