Have you ever fixed random memory corruption in an OS without memory protection?
Best case you trap on memory access to an address if your debugger supports it (ours didn't). Worst case you go through every pointer that is known to access nearby memory and go over the code very very carefully.
Of course it doesn't have to be a nearby pointer, it can be any pointer anywhere in the code base causing the problem, you just hope it is a nearby pointer because the alternative is a needle in a haystack.
I forget how we did find the root cause, I think someone may have just guessed bit flip in a pointer (vs overrun) and then un-bit-flipped every one of the possible bits one by one (not that many, only a few MB of memory so not many active bits for pointers...) and seen what was nearby (figuring what the originally intended address of the pointer was) and started investigating what pointer it was originally supposed to be.
Then after confirming it was a bit flip you have to figure out why the hell a subset of your devices are reliably seeing the exact same bit flipped, once every few days.
So to answer your question, you get a bug (memory is being corrupted), you do an initial investigation, and then provide an estimate. That estimate can very well be "no way to tell".
The principal engineer on this particular project (Microsoft Band) had a strict 0 user impacting bugs rule. Accordingly, after one of my guys spend a couple weeks investigating, the principal engineer assigned one of the top firmware engineers in the world to track down this one bug and fix it. It took over a month.