the cool thing about Typescript is that you never have to know any of this to deliver highly performant enterprise scale software

I think this is spot on. TS goes very very far without the gymnastics. Its good to know these things, but not even close to necessary to be productive. Not to mention IDE support for TS is on a very different level conpared to the shitshow that is Javascript.

Also, Angular dev spotted :)

You can do that with assembly and not know ANY high level language.

You might be interested in reading PG's treatise on "the blub paradox".

Can you even do that? I though you could only enterprise in secure languages, like Java