Advanced diffusion certainly benefited from the acquisition speed ups. That is its biggest challenge in my opinion preventing it from wider clinical adoption. It takes too long to get enough images for the models. Hyperpolarized MR will run into issue of lack of expertise in clinical imaging centers. There is already a shortage of good techs and MR companies are working to further automate the workflows. Unless there is a major benefit of the advanced techniques, people will stick to the bread and butter FSE and DWI.