There are YouTubers that have talked about their struggle to change content that they discuss in their channels. The general advice is, make a new channel for a new topic because of how fans and their attention work. One YouTuber I occasionally watch talked about how they at first got hate mail when changing their topic because people in their old topic perceived the YouTuber to be one of the only voices in that field.

My guess is Alex Jones is actually a big enough personality to be able to have a brand independent of his ideas. Not every creator has that luxury.