> If you are mocking anything in the standard library your code is probably structured poorly.

I like Hynek Schlawak's 'Don’t Mock What You Don’t Own' [1] phrasing, and while I'm not a fan of adding too many layers of abstraction to an application that hasn't proved that it needs them, the one structure I find consistently useful is to add a very thin layer over parts that do I/O, converting to/from types that you own to whatever is needed for the actual thing.

These layers should be boring and narrow (for example, never mock past validation you depend upon), doing as little conversion as possible. You can also rephrase the general purpose open()-type usage into application/purpose-specific usages of that.

Then you can either unittest.mock.patch these or provide alternate stub implementations for tests in a different way, with this this approach also translating easily to other languages that don't have the (double-edged sword) flexibility of Python's own unittest.mock.

[1] https://hynek.me/articles/what-to-mock-in-5-mins/