The author of ConTeXt (a TeX format similar to LaTeX) has some interesting comments on AsciiMath [0] [1]. Its space handling looks especially problematic; the example given in [0]

  o ox x = xo
  a ax x = xa
  ooxx=xo
  aaxx=xa
  ac+sinx+xsqrtx+sinsqrtx+sinsqrt(x)

  o ⊗ x = x o
  a a x x = x a
  ∞ × = x o
  a a × = x a
  a c + sin x + x √x + sin √x + sin √x

[0]: https://tug.org/TUGboat/tb36-2/tb113hagen.pdf#page=3

[1]: https://github.com/contextgarden/context/blob/e9bd55ec/tex/c...