I've also seen this happen for people who:

3. Leave long term relationships

4. Change careers or go back to university

5. See their parents pass away

6. Have children

7. Lose children

8. Completely change their physical health (diet/exercise/sleep) for the better/worse

9. Loss/change/gain of social groups, or specific friends

10. Gain/loss of religion

Most of these just sound like #1 to me.