> He elucidated the idea of your prefrontal cortex solidifying around 25, making personality changes MUCH more difficult.

It’s true that neuroplasticity tends to decline around this age, but there are several important caveats:

- Exercise, especially cardiovascular exercise, promotes the release of BDNF (brain-derived neurotrophic factor), which enhances neuroplasticity. Consistency matters, regular aerobic activity raises baseline BDNF levels, while sporadic exercise only causes short-term spikes. Studies even show that long-term cardiovascular exercise can alter brain structure.

- Belief in your ability to learn is associated with better learning outcomes and higher neuroplasticity markers. Whether this comes directly from belief or from the behaviors it encourages, it’s still practical advice. Don’t entertain thoughts that you can’t adapt or learn -- especially during exercise.

- Psychedelic experiences (with substances such as psilocybin, ketamine, or LSD) can open what’s called an “acute neuroplastic window”. During this time, brain network dynamics become more flexible and neuroplasticity increases. Surround yourself with the right people, ideas, books, during this period, and it can lead to dramatic positive change. But as this state can amplify both constructive and destructive influences, proceed with care and good research.