nodejs excels for me on flow control

theres effectts if you need app level control

theres caolan async if you need series and parallel controls

theres rxjs if you need observables

on web frameworks hono seems nice too. if you need performance, theres uwebsockets.js which beats all other web frameworks in http and websocket benchmarks.

for typesafety aside from typescript, theres ark, zod, valibot, etc.