1st get any job you can get at this time. Then look around for companies where you can have a career. This will likely weed out most small companies. Once you decide on the job you what to get then define a plan that outlines how to get the job you want. Part of that plan might mean getting any job you qualify for even if it's not what you want right now. Once you get your foot in the door then you can work towards getting promoted or transferred to the department where you want to work. Also, join any organization where you might get contacts that will help your career. A vast majority of jobs are found by who you know not what you know.

This might mean that you will have to move to a different city but you do what you need to do to survive.