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dyauspitr 9 hours ago

Isn’t this a largely solved problem after Alphafold?

the__alchemist 2 hours ago | parent | next [-]

Should an entry in a field preclude other ones. I encourage you to apply reductio-ad-absurdum here. Should Pepsi exist if Coke does? Should C exist if Fortran does?

samfriedman 9 hours ago | parent | prev [-]

Maybe they've been working on it, but got scooped?

zamadatix 7 hours ago | parent [-]

I don't think that's the case. The numbers in the paper suggest ~92% of the training data comes from pre-existing AI models, including AlphaFold, and they claim things like:

> We largely adopt the data pipeline implemented in Boltz-11 1https://github.com/jwohlwend/boltz (Wohlwend et al., 2024), which is an open-source replication of AlphaFold3

I believe the story here is largely that they simplified the architecture and scaled it to 3B parameters while maintaining leading results.