Easter Island! Both of those.

Tacrolimus was discovered in 1987 by a Japanese team led by pharmacologist Tohru Kino; it was among the first macrolide immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975.[45] It is produced by a soil bacterium, Streptomyces tsukubensis.[46] The name tacrolimus is derived from "Tsukuba macrolide immunosuppressant".[47]

https://en.m.wikipedia.org/wiki/Tacrolimus

When you study organic synthesis, these kinds of structures are the Holy Grail. Sometimes it takes dozens of steps, and an overall yield of just a few percent to make them synthetically.