Edit: nvm, brain fart. OP is correct.

> So being able to make the product without culturing the organism is key.

No, it isn't. The article talks about using chemical synthesis, rather than using a biological platform to express the product via genes.

"To convert the newly uncovered sequences into bioactive molecules, the team applied a synthetic bioinformatic natural products (synBNP) approach. They bioinformatically predicted the chemical structures of natural products directly from the genome data and then chemically synthesized them in the lab. With the synBNP approach, Brady and colleagues managed to turn the genetic blueprints from uncultured bacteria into actual molecules—including two potent antibiotics."

Isn't that saying the same thing a different way? Chemical synthesis is a way to make the assumed molecular product without culturing the organism.