As someone who grew up in northern Indiana; 100%. Northern and middle-Indiana are pretty culturally identical, alongside southern Michigan, most of illinois, western Ohio, then extending further into e.g. southern Wisconsin and Iowa.

But southern Indiana is very different. Definitely more similar to Kentucky & Cincinatti-area southern Ohio. You start to get "twangs" of Southern Americana as you approach the Ohio River Valley, which are basically non-existent in northern Indiana. Something about the air is different.

The biggest cultural shock people not from the midwest, and even people from the midwest, often experience about the area is IME northern mainland/non-UP Michigan. Its a truly unique region that is dissimilar to almost anywhere else I've visited; like mixing the cultures of the New England coast with rural farms.