> We have a pretty good mathematical representation of human knowledge...

> Swiss Cheese — there's a lot of cheese, but there's also a lot of holes.

Such hubris! Human knowledge is not like Swiss (mostly known with a few gaps). Human knowledge is like a high-dimensional fractal broccoli: a stem of hard-won knowledge surrounded by a vast frontier of unknown. The hardest part of pushing on the frontier is deciding where to push. Deciding what to research requires taste.