the Pfizer scientist explained that it was not biologically plausible: "RNA cannot reverse transcribe to DNA and transport from the cytoplasm to the nucleus and then integrate. That requires a set of molecules and enzymes that don't exist in humans and are largely reserved for retroviruses."

How does https://www.jefferson.edu/about/news-and-events/2021/6/disco... relate to what he is saying?

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abracadaniel 6 hours ago | parent [-]

All mRNA vaccines in use currently rely on modified nucleosides that cannot be replaced via our polymerases. Pseudouridine I think is the one.

	▲	bananabiscuit 5 hours ago \| parent [-]
		But didn't people also think unmodified RNA cannot be transcribed back into DNA until this article showed it was possible just four years ago? Also we are relying on mRNA vaccines being manufactured correctly, but that link in the chain of reasoning also doesn't seem to be too reliable as many studies seem to have shown, here's one of the more recent ones: https://pubmed.ncbi.nlm.nih.gov/40913499/