If by "genuinely confused" we are talking about what is generally called the emotion "confusion", then you need meta-cognition to even recognize your thinking is confused in order to then experience it. LLMs can model reflection by using their own output as input, but otherwise lack meta-cognitive processes. Through reflection they can later recognize what they did previously was wrong, but they will never experience "what I am currently thinking seems wrong/does not fit".

However "confusion" can also mean "mistaking one thing for another" or simply "doing the wrong thing", which is something computer programs have been able to fuck up since forever.