I've used XFCE as my main DE for around 10 years, (I switched to MacOs a year ago), I think mostly depends on your workflow, for me the best thing was that it gets out your way, you have a simple menu to select apps, a taskbar, and that's about it. I tested Gnome and KDE a few times over the years and for me they are more bloated than what I needed for my workflow, but I agree they feel more cohesive and the aesthetics are nicer.