Thats why you need to calculate which "eventual resolutions" divides down to values without fractions after your scaling has been applied.

So if you take a 2560x1440 panel, 160%/1.6 scaling factor will give you 1600x900, hence there won't be any artifacts. Between 100% and 200% there are maybe 5 combinations that will give you clean resolutions.

As an example:

Enter monitor Width (1920):

Enter monitor Height (1080):

1920x1080 at 100%

1600x900 at 120%

1536x864 at 125%

1280x720 at 150%

1200x675 at 160%

960x540 at 200%

800x450 at 240%

768x432 at 250%

640x360 at 300%

Aything besides these value WILL give you artifacts at some level.