Not for takeoff. Apollo astronauts used barbituates to help sleep, and scopolamine with dextroamphetamine during re-entry. Unsurprisingly the average HR during re-entry was rather higher than at launch! (source: https://space.stackexchange.com/a/31987 )

Gemini would likely have been similar, save for using Cyclizine during re-entry rather than scopolamine/dextroamphetamine.

Detailed info about the Apollo medkit: http://heroicrelics.org/info/csm/apollo-medical-kit.html

Less-detailed history of NASA medkits, mentioning Gemini: https://www.spacesafetymagazine.com/spaceflight/space-medici...