Purely anecdata, but my kids only use Linux at home and hadn't used anything else until they got (Windows and ChromeOS) computers at school, and they were able to get going quite easily. Honestly I think learning to use a mouse and keyboard is the hardest part since most of these kids grew up using tablets and phones as their first "computers."

Office compatibility still kind of sucks. It's very usable, but still quite a few papercuts. In my kids case though, Google Docs pretty much solves that problem so it's largely been a non-issue.