For some time now I've been supplying all my audio DSP plugins at airwindows.com pre-compiled on the Pi 400. (MIT open source, so it's not limited to that). The Pi version is included.

I mention this to make a point: you can't transform synths just by running some generic DSP code on a Pi and putting it in a box. Sound processing is also being transformed, and whether it's something like Hydrasynth generating poly aftertouch (but aliasing and not sounding that different from a VST) or Novation Peak/Summit receiving poly aftertouch (not generating :D ) but generating sound using custom hardware, sitting a VST on a Pi isn't going to get you a transformative synth.

Thing is, if you're able to dig into stuff like my DSP codebase that is actively under development AND plunk a VST synth onto a Pi AND do something interesting with the physical controls to direct the synth engine, that's starting to look transformative again. But just knowing about Pi isn't enough, you'll have to have a deep background in soundmaking and the ability to instrument-make in an interesting way.

If you have those things… game on. You can begin work FAR more cheaply than ever before, and that is how the Pi could be transforming synths.

I'm waiting for 24/96 audio hats to be common before I dig into this, even for stompboxes. I'm given to understand Electrosmith Daisy already has this, and that's a similar class of 'system on tiny board' that should be considered an audio Pi-like.