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ejstronge 3 days ago

This is an area I work in professionally so I keep up with the technical side of things.

> once you start adding more than one item to a cell it doesn't always work out.

Very true, but the amounts of money at stake would justify the relatively inexpensive cost of hooking cells up to the already-available ER/TR-responsive gene elements.

> but I don't believe any before have contained these immune escaping edits

Hard to say, I'm not an expert on immune escape. It's an old idea, however, so I imagine it's been used in other pre-clinical or Phase 1 settings.

> I believe all of those treatments are cancer treatments which allow for a different level of risk

I imagine you're speaking about allogeneic treatment? Either way, this isn't true at all - here's a list of current treatments for diabetes alone:

https://pmc.ncbi.nlm.nih.gov/articles/PMC12401705/#s4