Depends on your language, runtime, dev tooling.

I'm using IntelliJ for a Java project that takes a very long time to rebuild, re-spin and re-test. For E2E tests a 10-minute turn-around time would be blazingly fast.

But because of the tooling, once I've re-spun I can connect a debugger to the JVM and click a line in IntelliJ to set a breakpoint. Combined, that takes 5 seconds.

If I need to make small changes at that point I can usually rebuild it out exactly in the debugger to see how it executes, all while paused at that spot.