The only "problem" I've noticed in office vs. remote mixes, has been that it really unevens the playing field as far as office politics and influence goes.

The long short of it is that the remote workers become alienated, while the office gang has a good chance of becomes a good ol' boys club.

This is unfortunately very true. So often decisions were made only among the in-office part of the team. It is so tempting just to make a quick meeting in the office or even in the stereotypical kitchen, and discuss something, than to send out invites to remote guys, make sure they are available (even though they supposedly work 9-5 as everyone else), find a meeting room, click buttons etc.

> The long short of it is that the remote workers become alienated, while the office gang has a good chance of becomes a good ol' boys club.

This is what it becomes anyway whether I’m in office or not.