I'd rather optimize my $20 running shorts around my $1000 phone than the other way around tbh. No phone is comfortable in the pocket when running though, I used to use an arm strap and more recently just take the watch.

I carry two phones on me and if I run with just my SE it is comfortable enough to run with

But its not about optimisation it's about freedom. I don't enjoy having to baby around a lumbering 6 inch phone. I want my phone to optimise around me being able to not worrying about a brick sagging in my shorts.

The horizontal rear waistband zipper pocket on Patagonia Strider Pro running shorts genuinely makes my phone not noticeable at all during runs, unlike any other shorts I’ve tried. My experience is limited to smaller phones (6S, 12 Mini) without any cases, though.