Obviously just don’t forget aiming for where we see it now is not where it is and not where it will be in 100 years.

I have never seen anyone writing about us having solid reference points to travel that far in case we can reach those speeds.

If you miss you end up in some empty space you won’t be able to mine anything for fuel to have more shots.

Stuff keep moving predictably. Plus you can course correct during a fair bit of the acceleration / deceleration phase.