I use a different MUSL-based distro and do not find it an issue. A bigger problem on Alpine for me would be the limited package selection. In both cases, the solution for me would be Distrobox.

I tend to install an Arch Distrobox but Debian would work too. Both have massive software repos all running on Glibc. Anything not natively in the Alpine repos can be installed from the Distrobox repo instead. If it is a command-line app, it is just opening a terminal and typing. And GUI apps can be exported to the host app launcher where they launch and run normally.

I guess there is some “friction” but it is very minor. And if you like the distro otherwise, the overall experience is net positive.

Personally, I dislike Glibc. I am happier without it. And, when I have to use it, I can easily.