tl;dr read it with friends or drugs, or as a drug. Wild shit.

I was with a group of a couple friends who loved A Thousand Plateaus - we would read bits of it allowed together and laugh and generally have a good time talking about it. Probably the best way to have approached it.

Also on the advice of one of these folks, I read just the intro to ATP and then went for a walk outside without my phone or anything and stared into the woods while that clusterfuck of a concept-tangle just bounced around in my head. Then I slept on it, and later we started doing the group readings. Especially together with Guattari, it's almost more of a hallucinogenic substance than it is a book, and approaching it from all sides with a light heart is somehow helpful. Deleuze really doesn't seem interested in objections in ATP, he just wants to throw another concept at you and see if that one sticks instead.