I've been using Dvorak for around 6 years now, don't know what you mean with 'universally shitty default keybinding experience'. I don't have any issues either in Emacs or in applications which use the inferior CUA keybindings. I suppose if you want to use certain keybindings one-handed it could be awkward, but I prefer holding the modifier with the opposite hand (for example right hand control + left hand 'a').