uMatrix can be (somewhat) replicated by setting up uBlock Origin with multiple modes and configuring the "Relax Blocking Mode" hotkey.

So for instance you can start with an extremely restrictive mode like noJS/3rd-party/images, then with each time pressing the hotkey it relaxes to noJS/3rd-party, and then noJS/embeds, then no embeds, then full access (ie like uBO comes configured out-of-the-box).

https://github.com/gorilla/ublock/wiki/Keyboard-shortcuts

https://github.com/gorhill/uBlock/wiki/Advanced-settings#blo...

https://github.com/gorhill/uBlock/wiki/Blocking-mode

You still need a solution for cookies (eg CookieBro), and I still long for an "expanded expanded" mode on uBO's menu that reveals uMatrix columns, but this might help replace some of your use cases that currently require uMatrix.