Sure, but they will generally work better if you wear your seat belt. The car is designed with seat belts in mind, what happens to people who don't wear them is more of an afterthought. That's why modern cars will beep if people forget their seat belts. You're supposed to wear it.

Of course you're supposed to wear it. But the point of all those other features is to protect you, period. Shatterproof glass prevents pieces of the windshield from flying into the car and cutting you; its protection has nothing to do with seatbelts.