I have a plugin for Illustrator that has several options for helping to make sure your file gets saved regularly. I have it configured to just pop up a polite little warning after fifteen minutes of unsaved work.

Sometimes it grabs focus from whatever I'm doing in Illustrator and this is indeed slightly annoying but it is also useful since I want it to interrupt whatever I'm doing and make me ask myself if I am at a good place to save, and if I'm not, then to save as soon as I am.

Arguably this is still annoying but it is an annoyance I have explicitly asked for, knowing it'll be annoying.