Conversely, my grandmother's Alzheimer's became apparent when she was overdosing on either ibuprofen or aspirin, I forget which.

She would take a dose for a headache, ten minutes later she'd forgotten so she'd take another dose, ten minutes later, she had forgotten, take another dose, rinse and repeat until it's time for a trip to the hospital.

Maybe it wasn't ten minutes between, probably fewer given how much she'd ended up taking. This happened thirty or so years ago.