- Metamizole has a tendency to kill some percentage of native Brits and their descendants. Yet globally it's one of the most popular painkillers, it's even OTC in countries with sufficiently low numbers of British and related people. (Has anyone ever done research to try and figure out why Brits are on the order of 1000x-10000x more sensitive to that side effect?)

> Brits are on the order of 1000x-10000x more sensitive to that side effect?

That is wild.

If true, it would have to be genetic? I mean, unless it is chronic dehydration from their sense of humor?