I live in Brazil. We have broad access to non-steroidal anti-inflammatory drugs. Even the best-known medicines have unexpected and unknown adverse effects: in general and specifically in people with unexpected genetic, enzymatic, and protein variations. This has no solution. The medicine acts differently in each body, which is subtly diverse from the others. I see a lot of research criticizing any "old" general medicine and introducing the "new" one. I don't know if this is the case. Every medicine has its rush, half-life, and side effects, and its actions are not fully mapped. My preference for long-term treatments is: dipyrone. Short term: ibuprofen. Lymphatic pain: paracetamol. It may not make sense, but that's how I use it.

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moritzwarhier 3 days ago | parent [-]

Interesting how you put metamizole at #1 for long-term treatment. As far as my experience goes, many doctors do the same in Germany. On the other hand, I've heard that the medication is banned in many other countries.

I guess the safest way is to take up the treatment in a hospital, to check for immediate bad reactions.

On the other hand, like with many medications, severe allergies and individual sensibilities causing side effects often don't show up often in the short term, but rather suddenly after many dose intakes.

So I'm back where I started. Not disagreeing with what you say. It seems like these non-steroidal pain relief medications are poorly understood regarding their interaction with the whole body though.

Many OTC medications and even some prescribed ones (especially psychiatric medications) suffer from a very poor understanding and apparent lack of effort in improving the understanding of their mechanisms of action.

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davikr 3 days ago | parent [-]

Metamizole is safe to take on the long-term, which is not the case for NSAIDs (nephrotoxic) and corticosteroids.

	▲	moritzwarhier 3 days ago \| parent [-]
		I guess that's why metamizole is often a part of the standard treatment for mid-term exogenic pain here, for example after injuries or during some treatments involving pain. Not addictive, not hepatotoxic, not nephrotoxic. Seems the reason for the ban / harder regulation in some countries is about the disturbance of blood-forming in some individuals (which can also be deadly, but I have no idea of the quantified risk here). Ibuprofen and acetaminophen are more common for short-term treatment, at least that's what I've been taught. Avoid taking them on a schedule, take them as needed and at the lowest effective dosage. A.s.s. (lol) too, apart from the low-dose usage that some claim to be helpful with heart/artery diseases.