I'd have loved to use Typst but all journals I submit to ask for LaTeX. And it isn't just LaTeX they ask. They ask LaTeX with specific documentclasses. The mainstream academia and journals have so much tooling built around LaTeX and documentclasses and they have so much inertia that I am very pessimistic that Typst will ever get any "market share" in mainstream publishing!

Typst is made for the same target a Tex. Here I am asking if it is a reasonable replacement for Markdown or ReST in a target I don't think it was originally intended for. It would be interesting if the most popular forges enabled typst rendering for things like READMEs.