Deep Space Nine:

Julian Bashir: "It's not your fault things are the way they are."

Lee: "Everybody tells themselves that. And nothing ever changes."

I mean, DS9 was literally a TV serial, of course nothing ever changes.

Bashir's statement is a true one, made out of compassion. Lee's statement is almost comically/logically/obviously false in a real Universe, unless you're in a fictional TV series designed to not ever change. Except of course for the plot arc, which again, true to Bashir's statement is not anyone's fault.