Along similar lines but physically much smaller, there are currently about 3 or 4 boards[1] that have RP2350, DVI, USB host, and SD card, ranging in cost from about $15 to $40.

A particular sweet spot is emulating 8 and 16 bit systems, as latency can be just as good as an FPGA setup. The infoNES emulator has been running on RP2040 for a while, and I see projects for Sega Master System, Genesis, Apple II, and Mac in the works. But you can also write much more powerful software natively.

Likely it will be possible to adapt software between these various RP2350 systems.

[1]: https://github.com/DusterTheFirst/pico-dvi-rs/wiki/RP2350-DV...