Abstract

> ...Here we investigate the geographic clustering of common genetic variants that influence complex traits in a sample of ~450,000 individuals from Great Britain.... The level of geographic clustering is correlated with genetic associations between complex traits and regional measures of SES, health and cultural outcomes. Our results are consistent with the hypothesis that social stratification leaves visible marks in geographic arrangements of common allele frequencies and gene–environment correlations.

Social stratification affects who people choose to have children with, with people usually preferring and/or being restricted to their own strata. Seems obvious this would leave artifacts in the genome similar to geographic isolation of different groups.

I've also seen papers that talk about the fingerprint of past wars, genocides, and migrations on the genome.