Also all major GPUs now have machine learning based next frame prediction, it’s hard to imagine this wouldn’t be useful.

Plus whether there's further benefits available for the FSR/DLSS/XeSS type upscalers in knowing more about the scene. I'm reminded a bit of variable rate shading where if renderer analyses the scene for where detail levels will reward spending performance, could assign blocks (eg, 1x2, 4x2 pixels etc) to be shaded once instead of per-pixel to concentrate there. It's not exactly the same thing as the upscalers, but it seems a better foundation for a better output image compared to a blunt dropping the whole rendered resolution by a percentage. However, that's assuming traditional rendering before any ML gets involved which I think has proven its case in the past 7 years.

I think the other side to this is the difference between further integration of the engine and scaler/frame generation which would seem to involve a lot of low level tuning (probably per-title), and having a generic solution that uplifts as many titles as possible even if there's "perfect is the enemy of good" left on the table.