Iroh is much better suited for the application layer. You can multiplex multiple QUIC streams over the same connection, each for a specific purpose. All you need is access to QUIC, no virtual network interface.

It’s a bit like gRPC except you control each byte stream and can use one for, say, a voice call while you use another for file transfer and yet another for simple RPC. It’s probably most similar to WebRTC but you have more options than SCTP and RTMP(?).