The social effects at scale are what bothers me. Just wait a century until employers put "no genetic defects" in their job applications. Or parents who decide to have old fashioned non-designer babies have trouble getting their kids insured. Or homophobia will become normalized again because "they should have fixed it in the womb". Is this a sufficient reason to not prevent genetic defects? Who can say.

This was the premises for the movie Gattaca (1997). One of my favorite movies as a kid.